Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies

Introduction Maternal vitamin D status during pregnancy has been suggested to have a role in childhood adiposity development, but results are conflicting. Our aims were investigate [1] the relationships between maternal 25-hydroxyvitamin (25OHD) and child’s body mass index (BMI) risk of overweight at 5 years age, [2] pre-pregnancy BMI as effect modifier for these associations. Methods Data sources included subsample from Norwegian Mother, Father Child Cohort Study (MoBa sub-cohort; N = 2,744) Swedish GraviD cohort study ( 891). 25OHD was analyzed gestational week 18 MoBa sub-cohort 10 cohort. In sub-cohort, parents reported their documented measures weight length or height health card routine check-up. cohort, this information collected directly medical records. Childhood (including obesity) identified using International Obesity Task Force cut-offs. Linear logistic regression models used association age each separately, pooled dataset. Results analysis, <30 nmol/L associated with lower children not overweight. Interaction analysis showed that predominant among mothers ≥25 kg/m 2 . Conclusion Low status, particularly obesity, predicted five-year-old children. However, there no evidence an on